{"title":"Weight loss Offering","description":"\u003cp\u003eStacks and products for weight loss\u003c\/p\u003e","products":[{"product_id":"mots-c","title":"MOTS-C","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp *{box-sizing:border-box}.pp-pdp h2,.pp-pdp h3{color:var(--nv);font-weight:800;line-height:1.15;margin:0 0 14px}.pp-pdp p{color:var(--ink);margin:0 0 14px}.pp-pdp p:last-child{margin-bottom:0}.pp-pdp a{color:#0d6c8a}.pp-pdp .pp-in{max-width:1180px;margin:0 auto;padding:0 24px}.pp-pdp .pp-kick{color:var(--tl);font-size:12px;letter-spacing:2.16px;text-transform:uppercase;font-weight:600;margin:0 0 12px}.pp-pdp .pp-sec{padding:56px 0}.pp-pdp .pp-alt{background:var(--sf)}.pp-pdp .pp-sec h2{font-size:30px}.pp-pdp .pp-prose 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.pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eMetabolic health, energy and insulin sensitivity\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e2mg daily, 5 on\/2 off\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e5 days (10mg) \/ 4 weeks (40mg)\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eMOTS-C is unusual: it is coded by your mitochondria — the parts of the cell that make energy — rather than by the DNA in the cell nucleus.\u003c\/p\u003e\n\u003cp\u003eIt is used for metabolic health: insulin sensitivity, energy, body composition and exercise capacity. It is taken in the morning, five days on and two days off, ideally 30 to 60 minutes before training or food. Your own levels rise with exercise and fall with age, which is the basis of most of the interest in it.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eA 16-amino-acid peptide encoded by mitochondrial DNA\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eInsulin sensitivity, metabolic health, energy, exercise capacity\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e2mg daily, 5 days on \/ 2 off, for 4–8 weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eCells have a master switch that flips them from storing energy to burning it. MOTS-C turns that switch on.\u003c\/p\u003e\n\u003cp\u003eIt does it indirectly. Rather than binding a receptor, it shifts one metabolic pathway so that a natural activator builds up inside the cell — and that activator flips the switch.\u003c\/p\u003e\n\u003cp\u003eDownstream, mouse studies reported more glucose taken into muscle without needing extra insulin, more fat burned, and resistance to diet-induced weight gain.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-mots-c.png?v=1785967535\" alt=\"MOTS-C molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eMOTS-C belongs to a small class of mitochondrial-derived peptides — short open reading frames encoded within mitochondrial ribosomal RNA genes rather than nuclear DNA. Humanin and the SHLP series arise from the 16S rRNA gene; MOTS-C from the 12S. Lee et al. (Cell Metabolism, 2015) identified the peptide, showed it circulates, and characterised its metabolic activity.\u003c\/p\u003e\n\u003cp\u003eIts mechanism is indirect and unusual. Rather than binding a cell-surface receptor, MOTS-C acts on the folate-methionine one-carbon cycle, suppressing flux through de novo purine biosynthesis. The consequence is accumulation of AICAR — 5-aminoimidazole-4-carboxamide ribonucleotide — an endogenous intermediate that allosterically activates AMP-activated protein kinase. AMPK activation is therefore downstream of a metabolite shift rather than of direct binding, which separates MOTS-C from biguanides such as metformin, which raise the AMP:ATP ratio by inhibiting respiratory complex I, and from direct AMPK agonists.\u003c\/p\u003e\n\u003cp\u003eOnce AMPK is engaged the profile is conventional catabolic signalling: increased GLUT4 translocation and insulin-independent glucose uptake in skeletal muscle, increased fatty acid oxidation, and suppression of lipogenic and gluconeogenic programmes. In the original mouse work this presented as resistance to diet-induced obesity and improved insulin sensitivity.\u003c\/p\u003e\n\u003cp\u003eMOTS-C also has a nuclear role. Kim et al. (Cell Metabolism, 2018) reported that under metabolic stress the peptide translocates to the nucleus, associates with stress-responsive transcription factors and regulates antioxidant response element-driven genes. That gives it a retrograde signalling function — mitochondria issuing adaptive instructions to the nuclear genome — and it is the feature drawing most current research attention.\u003c\/p\u003e\n\u003cp\u003eReynolds et al. (Nature Communications, 2021) characterised MOTS-C as exercise-responsive: circulating and skeletal muscle levels rise with exercise in humans, and administration to aged mice improved measures of physical capacity and muscle homeostasis. That work underlies its description as an exercise-mimetic in the literature. Endogenous levels decline with age, and a mitochondrial DNA variant altering the peptide sequence has been examined in relation to longevity in East Asian cohorts.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eMade by your mitochondria\u003c\/h3\u003e\n\u003cp\u003eOne of a small group of peptides coded in mitochondrial DNA rather than the cell nucleus.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eTurns on the cell's energy-burning switch\u003c\/h3\u003e\n\u003cp\u003eIt activates AMPK — the master regulator that shifts cells from storing to burning fuel.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eImproved insulin sensitivity in mice\u003c\/h3\u003e\n\u003cp\u003eThe original work reported better glucose handling and resistance to diet-induced obesity.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eRises with exercise in humans\u003c\/h3\u003e\n\u003cp\u003eHuman levels increase with exercise; ageing mice given it showed improved physical capacity.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eMOTS-C 10mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 1ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 1ml of water added, each 0.1ml (10 units) you draw = 1mg of MOTS-C.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e2mg daily\u003c\/td\u003e\n\u003ctd\u003e20 units (0.2ml)\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 5 days\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Morning preferred, 30 to 60 minutes before exercise or food. 5 days on, 2 days off.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 4 to 8 weeks, then reassess.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eMOTS-C 40mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 2mg of MOTS-C.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e2mg daily\u003c\/td\u003e\n\u003ctd\u003e10 units (0.1ml)\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 4 weeks\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Morning preferred, 30 to 60 minutes before exercise or food. 5 days on, 2 days off.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 4 to 8 weeks, then reassess.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat makes MOTS-C different from other peptides?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eIts origin. Almost all research peptides are fragments or analogues of nuclear-encoded proteins. MOTS-C is transcribed from mitochondrial DNA, within the 12S rRNA gene, which places it in the small class of mitochondrial-derived peptides alongside humanin and the SHLPs.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eDoes MOTS-C bind a receptor?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNo specific cell-surface receptor has been established. The characterised mechanism is metabolic: inhibition of folate-cycle flux, accumulation of AICAR, and consequent AMPK activation. Its nuclear translocation under stress is a separate, intracellular mode of action.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is it described as an exercise mimetic?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eReynolds et al. (Nature Communications, 2021) showed that MOTS-C rises in muscle and plasma following exercise, and that administering it to aged mice improved measures of running capacity and muscle homeostasis. The term describes an overlap in signalling, not an equivalence to training.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the difference between the 10mg and 40mg vials?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003ePeptide mass only; the material is from the same synthesis and assay standard. The 40mg vial is intended for extended experimental series and gives a higher concentration for a given diluent volume.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our \u003ca href=\"\/pages\/quality-standards\"\u003equality standards page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from within South Africa with tracking. Timelines by region and courier are set out on our \u003ca href=\"\/pages\/delivery-process\"\u003edelivery process page\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat is the returns policy?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eUnopened vials in original condition may be returned within the stated window; full terms are in our \u003ca href=\"\/policies\/refund-policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/energy-mitochondrial-peptides\"\u003eAlso in Cellular Energy \u0026amp; Mitochondrial\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/nad\"\u003eNAD+\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/retatrutide\"\u003eRetatrutide\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/cjc-1295-w-dac\"\u003eCJC-1295 w DAC\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/cellular-longevity-peptide-stack\"\u003eCellular Longevity Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/metabolic-reset-peptide-stack\"\u003eMetabolic Reset Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/fat-loss-peptide-stack\"\u003eFat Loss Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/lean-growth-peptide-stack\"\u003eLean Growth Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What makes MOTS-C different from other peptides?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Its origin. Almost all research peptides are fragments or analogues of nuclear-encoded proteins. MOTS-C is transcribed from mitochondrial DNA, within the 12S rRNA gene, which places it in the small class of mitochondrial-derived peptides alongside humanin and the SHLPs.\"}},{\"@type\":\"Question\",\"name\":\"Does MOTS-C bind a receptor?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No specific cell-surface receptor has been established. The characterised mechanism is metabolic: inhibition of folate-cycle flux, accumulation of AICAR, and consequent AMPK activation. Its nuclear translocation under stress is a separate, intracellular mode of action.\"}},{\"@type\":\"Question\",\"name\":\"How is it described as an exercise mimetic?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Reynolds et al. (Nature Communications, 2021) showed that MOTS-C rises in muscle and plasma following exercise, and that administering it to aged mice improved measures of running capacity and muscle homeostasis. The term describes an overlap in signalling, not an equivalence to training.\"}},{\"@type\":\"Question\",\"name\":\"What is the difference between the 10mg and 40mg vials?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Peptide mass only; the material is from the same synthesis and assay standard. The 40mg vial is intended for extended experimental series and gives a higher concentration for a given diluent volume.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our quality standards page at \/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from within South Africa with tracking. Timelines by region and courier are set out on our delivery process page at \/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"What is the returns policy?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Unopened vials in original condition may be returned within the stated window; full terms are in our refund policy at \/policies\/refund-policy.\"}}]}\u003c\/script\u003e","brand":"Purist Peptides","offers":[{"title":"10mg","offer_id":51215244886314,"sku":"PP-MOTS-10","price":750.0,"currency_code":"ZAR","in_stock":true},{"title":"40mg","offer_id":52039590609194,"sku":"PP-MOTS-40","price":2000.0,"currency_code":"ZAR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-peptides-mots-c-10mg-energy-metabolism-endurance-longevity-vial.jpg?v=1784719852"},{"product_id":"retatrutide","title":"Retatrutide","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp *{box-sizing:border-box}.pp-pdp h2,.pp-pdp h3{color:var(--nv);font-weight:800;line-height:1.15;margin:0 0 14px}.pp-pdp p{color:var(--ink);margin:0 0 14px}.pp-pdp p:last-child{margin-bottom:0}.pp-pdp 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34px;font-size:15px;color:var(--mut)}.pp-pdp .pp-step li:before{counter-increment:s;content:counter(s);position:absolute;left:0;top:1px;width:22px;height:22px;border-radius:50%;background:var(--tl);color:#fff;font-size:12px;font-weight:800;display:flex;align-items:center;justify-content:center}.pp-pdp .pp-warn{background:#fff6e5;border-left:4px solid #e0a33a;padding:13px 18px;border-radius:0 8px 8px 0;font-size:14.5px;color:var(--ink);margin:0 0 16px}.pp-pdp .pp-warn p{margin:0 0 6px;font-size:14.5px}.pp-pdp .pp-warn p:last-child{margin:0}.pp-pdp .pp-vbox{border:1px solid var(--ln);border-radius:12px;padding:26px;margin:0 0 22px;background:#fff;box-shadow:0 2px 10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eWeight loss — triple receptor action\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e1mg → 9mg weekly\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eTitrated over 8+ weeks\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eRetatrutide is the newest generation of weight-loss compound. Where semaglutide hits one receptor and tirzepatide hits two, retatrutide hits three.\u003c\/p\u003e\n\u003cp\u003eThe third one is the difference. GLP-1 and GIP reduce how much you eat; the glucagon receptor increases how much energy you burn. It is a once-weekly injection, titrated up slowly over about eight weeks.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eA single molecule acting on GLP-1, GIP and glucagon receptors\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eWeight loss and metabolic health\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003eOnce weekly, titrated 1mg → 9mg over 8+ weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eTwo of the three receptors work on the intake side: less appetite, slower stomach emptying, better insulin response to food. This is the same territory as semaglutide and tirzepatide.\u003c\/p\u003e\n\u003cp\u003eThe third — the glucagon receptor — works on the output side, in the liver, increasing energy expenditure and fat burning. That is what neither of the others does.\u003c\/p\u003e\n\u003cp\u003eTitrate slowly. The gastrointestinal side effects are dose-related, and there is no requirement to reach the top dose if a lower one is working.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-retatrutide.png?v=1785967669\" alt=\"Retatrutide molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eRetatrutide is a unimolecular agonist at three class B G-protein-coupled receptors: the glucose-dependent insulinotropic polypeptide receptor (GIPR), the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR). Each is coupled principally to Gs, so agonism at all three raises intracellular cAMP in the relevant target tissues, but the tissue distribution of the three receptors is what produces the compound's distinct profile.\u003c\/p\u003e\n\u003cp\u003eGLP-1R agonism acts on pancreatic beta cells to potentiate glucose-dependent insulin secretion, and on hindbrain and hypothalamic circuits governing satiety and gastric emptying. GIPR signalling contributes a further incretin effect at the beta cell and has additional actions in adipose tissue; its role in energy balance remains an area of active argument, since both GIPR agonism and antagonism have shown weight-lowering effects in different models. The glucagon receptor arm is the substantive point of difference. GCGR is expressed densely in hepatocytes, where cAMP-driven signalling raises hepatic lipid oxidation and energy expenditure. In principle this adds a catabolic, expenditure-side mechanism to the intake-side mechanisms supplied by GLP-1R and GIPR — a different axis of action from dual GIP\/GLP-1 agonists such as tirzepatide, which lack glucagon receptor activity, and from selective GLP-1 agonists such as semaglutide.\u003c\/p\u003e\n\u003cp\u003eThe counterweight is that unopposed glucagon receptor agonism is hyperglycaemic. The design problem for triple agonists is therefore ratio: the incretin components must be sufficient to offset the glycaemic consequence of the glucagon component. Retatrutide's receptor potency ratios were selected on this basis.\u003c\/p\u003e\n\u003cp\u003eStructurally, retatrutide is a synthetic peptide carrying a fatty diacid substitution that promotes reversible albumin binding, extending circulating half-life sufficiently for once-weekly administration in the clinical protocols in which it was studied. Non-canonical residues in the backbone reduce susceptibility to dipeptidyl peptidase-4 cleavage.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eThree receptors, one molecule\u003c\/h3\u003e\n\u003cp\u003eGLP-1 and GIP reduce intake; the glucagon arm raises energy expenditure.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003ePhase 2 obesity trial in NEJM\u003c\/h3\u003e\n\u003cp\u003eResults were published in the New England Journal of Medicine in 2023.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eAlso trialled in type 2 diabetes\u003c\/h3\u003e\n\u003cp\u003eA separate phase 2 trial was published in The Lancet in 2023.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eThe glucagon arm is the differentiator\u003c\/h3\u003e\n\u003cp\u003eDual GIP\/GLP-1 agonists such as tirzepatide have no glucagon receptor activity.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eRetatrutide 30mg (GLP-3RT)\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 3ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 3ml of water added, each 0.1ml (10 units) you draw = 1mg of Retatrutide.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeek 1\u003c\/td\u003e\n\u003ctd\u003e1mg once weekly\u003c\/td\u003e\n\u003ctd\u003e10 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeek 2\u003c\/td\u003e\n\u003ctd\u003e1.5mg once weekly\u003c\/td\u003e\n\u003ctd\u003e15 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeeks 3 to 4\u003c\/td\u003e\n\u003ctd\u003e3mg once weekly\u003c\/td\u003e\n\u003ctd\u003e30 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeeks 5 to 6\u003c\/td\u003e\n\u003ctd\u003e4.5mg once weekly\u003c\/td\u003e\n\u003ctd\u003e45 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeeks 7 to 8\u003c\/td\u003e\n\u003ctd\u003e6mg once weekly\u003c\/td\u003e\n\u003ctd\u003e60 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeek 9 onwards\u003c\/td\u003e\n\u003ctd\u003e9mg (peak) once weekly\u003c\/td\u003e\n\u003ctd\u003e90 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"pp-warn\"\u003e\n\u003cp\u003eThis 30mg schedule is the gentler ramp, intended for a first cycle.\u003c\/p\u003e\n\u003cp\u003eProgress through each step only when comfortable at the current dose.\u003c\/p\u003e\n\u003cp\u003eThere is no requirement to reach the peak dose. Stay at the dose that works for you.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Once weekly on the same day each week.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e Continue at your comfortable maintenance dose for as long as needed. Reassess regularly.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eRetatrutide 60mg (GLP-3RT)\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 3mg of Retatrutide.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeeks 1 to 2\u003c\/td\u003e\n\u003ctd\u003e1.5mg once weekly\u003c\/td\u003e\n\u003ctd\u003e5 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeeks 3 to 4\u003c\/td\u003e\n\u003ctd\u003e3mg once weekly\u003c\/td\u003e\n\u003ctd\u003e10 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeeks 5 to 6\u003c\/td\u003e\n\u003ctd\u003e6mg once weekly\u003c\/td\u003e\n\u003ctd\u003e20 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeeks 7 to 8\u003c\/td\u003e\n\u003ctd\u003e9mg once weekly\u003c\/td\u003e\n\u003ctd\u003e30 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeek 9 onwards\u003c\/td\u003e\n\u003ctd\u003e12mg (peak) once weekly\u003c\/td\u003e\n\u003ctd\u003e40 units\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"pp-warn\"\u003e\n\u003cp\u003eThe 60mg schedule starts higher and peaks higher. It is intended for someone who has already completed a cycle, not for a first course.\u003c\/p\u003e\n\u003cp\u003eProgress through each step only when comfortable at the current dose.\u003c\/p\u003e\n\u003cp\u003eThere is no requirement to reach the peak dose. Stay at the dose that works for you.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Once weekly on the same day each week.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e Continue at your comfortable maintenance dose for as long as needed. Reassess regularly.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat distinguishes retatrutide from tirzepatide?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eTirzepatide is a dual agonist at the GIP and GLP-1 receptors. Retatrutide adds agonism at the glucagon receptor, which is expressed principally in the liver and is associated in research models with increased hepatic lipid oxidation and energy expenditure. The two compounds therefore differ in mechanism, not only in potency.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat has retatrutide been studied for?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eIts published phase 2 programme covered obesity (Jastreboff et al., NEJM 2023) and type 2 diabetes (Rosenstock et al., Lancet 2023). Substudies have examined body composition change. Later-phase trials under the TRANSCEND programme have been reported. Purist supplies the compound for laboratory research only.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy does the glucagon receptor component matter?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eGlucagon receptor agonism on its own raises blood glucose. In a triple agonist the incretin components are intended to offset that effect, so the receptor potency ratio is a central design parameter. This balance is the principal subject of interest in the triple-agonist literature.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eIs the 60mg vial a different compound to the 30mg vial?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eNo. Both vials contain the same lyophilised compound; they differ only in the mass supplied. The larger vial reduces the number of reconstitutions required across an extended research protocol.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at \u003ca href=\"\/pages\/quality-standards\"\u003eQuality Standards\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from South Africa, with timelines varying by region and courier. Current dispatch and transit windows are set out at \u003ca href=\"\/pages\/delivery-process\"\u003eDelivery Process\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eCan I return an order?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eBecause these are laboratory compounds, returns are not accepted once an order has shipped. If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out in our \u003ca href=\"\/policies\/refund-policy\"\u003eRefund Policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/fat-loss-peptides\"\u003eAlso in Fat Loss \u0026amp; Metabolic Research\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/tesamorelin\"\u003eTesamorelin\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/mots-c\"\u003eMOTS-C\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/aod-9604\"\u003eAOD 9604\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/fat-loss-peptide-stack\"\u003eFat Loss Peptide Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/visceral-fat-peptide-stack\"\u003eVisceral Fat Peptide Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/metabolic-reset-peptide-stack\"\u003eMetabolic Reset Peptide Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What distinguishes retatrutide from tirzepatide?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Tirzepatide is a dual agonist at the GIP and GLP-1 receptors. Retatrutide adds agonism at the glucagon receptor, which is expressed principally in the liver and is associated in research models with increased hepatic lipid oxidation and energy expenditure. The two compounds therefore differ in mechanism, not only in potency.\"}},{\"@type\":\"Question\",\"name\":\"What has retatrutide been studied for?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Its published phase 2 programme covered obesity (Jastreboff et al., NEJM 2023) and type 2 diabetes (Rosenstock et al., Lancet 2023). Substudies have examined body composition change. Later-phase trials under the TRANSCEND programme have been reported. Purist supplies the compound for laboratory research only.\"}},{\"@type\":\"Question\",\"name\":\"Why does the glucagon receptor component matter?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Glucagon receptor agonism on its own raises blood glucose. In a triple agonist the incretin components are intended to offset that effect, so the receptor potency ratio is a central design parameter. This balance is the principal subject of interest in the triple-agonist literature.\"}},{\"@type\":\"Question\",\"name\":\"Is the 60mg vial a different compound to the 30mg vial?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No. Both vials contain the same lyophilised compound; they differ only in the mass supplied. The larger vial reduces the number of reconstitutions required across an extended research protocol.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at https:\/\/puristpeptides.co.za\/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from South Africa, with timelines varying by region and courier. Current dispatch and transit windows are set out at https:\/\/puristpeptides.co.za\/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"Can I return an order?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Because these are laboratory compounds, returns are not accepted once an order has shipped. If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out at https:\/\/puristpeptides.co.za\/policies\/refund-policy.\"}}]}\u003c\/script\u003e","brand":"Purist Peptides","offers":[{"title":"30mg","offer_id":51217973215530,"sku":"PP-RETA-30","price":2000.0,"currency_code":"ZAR","in_stock":true},{"title":"60mg","offer_id":52039563870506,"sku":"PP-RETA-60","price":3500.0,"currency_code":"ZAR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-peptides-retatrutide-30mg-glp1-gip-glucagon-research-peptide.jpg?v=1784717630"},{"product_id":"tesamorelin","title":"Tesamorelin","description":"\u003cstyle\u003e.pp-pdp{--nv:#0d2233;--tl:#3a9ab5;--ink:#1f2937;--mut:#5b6b7a;--ln:#e3e8ee;--sf:#f5f8fa;--gr:#1E9E5A;font-family:Montserrat,-apple-system,sans-serif;color:var(--ink);line-height:1.6;margin:34px 0 0;width:100%;max-width:100%;overflow-x:hidden;background:#fff;text-align:left}.pp-pdp *{box-sizing:border-box}.pp-pdp h2,.pp-pdp 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.pp-step{counter-reset:s;list-style:none;padding:0;margin:0 0 18px}.pp-pdp .pp-step li{position:relative;padding:0 0 11px 34px;font-size:15px;color:var(--mut)}.pp-pdp .pp-step li:before{counter-increment:s;content:counter(s);position:absolute;left:0;top:1px;width:22px;height:22px;border-radius:50%;background:var(--tl);color:#fff;font-size:12px;font-weight:800;display:flex;align-items:center;justify-content:center}.pp-pdp .pp-warn{background:#fff6e5;border-left:4px solid #e0a33a;padding:13px 18px;border-radius:0 8px 8px 0;font-size:14.5px;color:var(--ink);margin:0 0 16px}.pp-pdp .pp-warn p{margin:0 0 6px;font-size:14.5px}.pp-pdp .pp-warn p:last-child{margin:0}.pp-pdp .pp-vbox{border:1px solid var(--ln);border-radius:12px;padding:26px;margin:0 0 22px;background:#fff;box-shadow:0 2px 10px rgba(13,34,51,.05)}.pp-pdp .pp-vbox h3{font-size:18px;margin:0 0 18px;padding-bottom:12px;border-bottom:2px solid var(--tl)}.pp-pdp .pp-vbox p{font-size:15px}.pp-pdp .pp-sub{font-size:12px;letter-spacing:1.5px;text-transform:uppercase;font-weight:800;color:var(--tl);margin:0 0 10px}.pp-pdp .pp-cta{display:inline-block;background:var(--gr);color:#fff!important;font-weight:800;font-size:15px;padding:15px 32px;border-radius:6px;text-decoration:none;margin-top:8px}.pp-pdp .pp-cta:hover{filter:brightness(1.08)}@media(max-width:900px){.pp-pdp .pp-tldr li{display:block}.pp-pdp .pp-tldr b{display:block;margin-bottom:2px}.pp-pdp .pp-vbox{padding:20px}.pp-pdp .pp-ov{padding:22px}}\u003c\/style\u003e\n\u003cdiv class=\"pp-pdp\"\u003e\n\u003csection class=\"pp-facts\" id=\"specs\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v3\"\u003eVisceral (deep abdominal) fat reduction\u003c\/b\u003e\u003cspan\u003eWhat it is used for\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e2mg daily\u003c\/b\u003e\u003cspan\u003eTypical dose\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003e10 days per vial\u003c\/b\u003e\u003cspan\u003eOne vial lasts\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fi\"\u003e\n\u003cb class=\"pp-v2\"\u003eIndependently HPLC tested\u003c\/b\u003e\u003cspan\u003eEvery batch\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\" id=\"overview\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eOverview\u003c\/p\u003e\n\u003ch2\u003eIn plain English\u003c\/h2\u003e\n\u003cdiv class=\"pp-ov pp-prose\"\u003e\n\u003cp\u003eTesamorelin is a stabilised version of the brain signal that tells the pituitary to release growth hormone. It is the only compound in this category with regulatory approval anywhere — approved in the US for a specific HIV-related condition.\u003c\/p\u003e\n\u003cp\u003eIt is used for visceral fat: the deep abdominal fat that sits around the organs, as distinct from the fat you can pinch. That distinction is the whole reason people choose it.\u003c\/p\u003e\n\u003cul class=\"pp-tldr\"\u003e\n\u003cli\u003e\n\u003cb\u003eWhat it is\u003c\/b\u003e\u003cspan\u003eA stabilised analogue of growth hormone-releasing hormone\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMainly used for\u003c\/b\u003e\u003cspan\u003eReducing visceral (deep abdominal) fat\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTypical protocol\u003c\/b\u003e\u003cspan\u003e2mg once daily in the evening, 8–12 weeks\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"how\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cdiv class=\"pp-g2\"\u003e\n\u003cdiv class=\"pp-prose\"\u003e\n\u003cp class=\"pp-kick\"\u003eHow it works\u003c\/p\u003e\n\u003ch2\u003eWhat it actually does\u003c\/h2\u003e\n\u003cp\u003eIt works on your pituitary, prompting it to release more of your own growth hormone — rather than injecting growth hormone directly.\u003c\/p\u003e\n\u003cp\u003eThat matters. Because the release is still your body's own pulsing system, your natural feedback brakes stay in place instead of being overridden.\u003c\/p\u003e\n\u003cp\u003eThe growth hormone then raises fat-breakdown activity. Visceral fat carries more growth hormone receptors than fat under the skin and responds more strongly, which is why the effect shows up there first.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-media\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-tesamorelin.png?v=1785967669\" alt=\"Tesamorelin molecular structure and mechanism of action diagram\" width=\"1200\" height=\"1200\" decoding=\"async\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"pp-ac pp-more\"\u003e\u003csummary\u003eThe science in detail\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\n\u003cp\u003eTesamorelin is a stabilised analogue of human growth hormone-releasing hormone. The native molecule, GHRH(1-44), is rapidly inactivated in circulation by dipeptidyl peptidase-4, which cleaves the N-terminal dipeptide and abolishes receptor activity. Tesamorelin carries a trans-3-hexenoyl group attached to the N-terminal tyrosine, which sterically obstructs that cleavage and materially extends the functional half-life while preserving affinity for the receptor.\u003c\/p\u003e\n\u003cp\u003eThe target is the GHRH receptor, a class B G-protein-coupled receptor expressed on pituitary somatotrophs. Agonism raises intracellular cAMP, activates protein kinase A, and increases both the synthesis and the pulsatile release of endogenous growth hormone. This is the mechanistically important distinction from exogenous recombinant growth hormone: tesamorelin amplifies the animal's own secretory pulses rather than imposing a continuous exogenous concentration, so the pituitary's negative feedback loops — somatostatin tone and IGF-1 feedback — remain intact and continue to constrain the response.\u003c\/p\u003e\n\u003cp\u003eDownstream, elevated growth hormone acts on hepatic and peripheral GH receptors, raising IGF-1 and increasing hormone-sensitive lipase activity in adipose tissue. Visceral adipose tissue is comparatively rich in GH receptors and lipolytically responsive, which is the mechanistic basis for the tissue-selective findings reported in the clinical literature.\u003c\/p\u003e\n\u003cp\u003eThat literature is unusually solid for this compound class. Falutz et al. (New England Journal of Medicine, 2007) reported reductions in visceral adipose tissue in a randomised placebo-controlled trial in patients with HIV-associated excess abdominal fat, findings extended in a pooled analysis of two phase 3 trials. Stanley et al. (Lancet HIV, 2019) subsequently reported effects on hepatic fat in a randomised, double-blind, multicentre trial of non-alcoholic fatty liver disease in HIV.\u003c\/p\u003e\n\u003cp\u003eTesamorelin differs from growth hormone secretagogues such as ipamorelin, which act at the ghrelin receptor (GHS-R1a) rather than the GHRH receptor. The two pathways are distinct and, in research models, additive; CJC-1295 is the closer comparator, being a GHRH analogue of different design.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eEvidence\u003c\/p\u003e\n\u003ch2\u003eWhat the research shows\u003c\/h2\u003e\n\u003cdiv class=\"pp-cards\"\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e01\u003c\/span\u003e\u003ch3\u003eTargets deep abdominal fat\u003c\/h3\u003e\n\u003cp\u003eVisceral fat is richer in growth hormone receptors and more responsive, which is why results concentrate there.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e02\u003c\/span\u003e\u003ch3\u003eUses your own hormone release\u003c\/h3\u003e\n\u003cp\u003eIt amplifies the pituitary's natural pulses rather than replacing them with a flat exogenous dose.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e03\u003c\/span\u003e\u003ch3\u003eBacked by a NEJM trial\u003c\/h3\u003e\n\u003cp\u003eVisceral fat reduction was reported in a New England Journal of Medicine randomised trial.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-card\"\u003e\n\u003cspan class=\"pp-num\"\u003e04\u003c\/span\u003e\u003ch3\u003eAlso studied for liver fat\u003c\/h3\u003e\n\u003cp\u003eA randomised trial published in Lancet HIV examined its effect on fat in the liver.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"prep\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eMixing \u0026amp; dosage\u003c\/p\u003e\n\u003ch2\u003eHow to mix and dose it\u003c\/h2\u003e\n\u003cdiv class=\"pp-prose pp-wide\"\u003e\n\u003cp\u003eThese are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA 3ml vial of bacteriostatic water is included free with every peptide vial you order\u003c\/strong\u003e, so you have what you need to mix this on arrival.\u003c\/p\u003e\n\u003cdiv class=\"pp-vbox\"\u003e\n\u003ch3\u003eTesamorelin 20mg\u003c\/h3\u003e\n\u003cp class=\"pp-sub\"\u003eStep 1 — mix your vial\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eDraw up 2ml of bacteriostatic water into a syringe\u003c\/li\u003e\n\u003cli\u003eWipe the rubber top of your vial with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003eInsert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder\u003c\/li\u003e\n\u003cli\u003eGently roll the vial between your palms until the powder dissolves completely\u003c\/li\u003e\n\u003cli\u003eDo not shake\u003c\/li\u003e\n\u003cli\u003eAllow to settle in the fridge for 5–10 minutes. The liquid should look clear\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStep 2 — draw \u0026amp; inject your dose\u003c\/p\u003e\n\u003cp\u003eUse a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWith 2ml of water added, each 0.1ml (10 units) you draw = 1mg of Tesamorelin.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pp-dose\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStage\u003c\/th\u003e\n\u003cth\u003eDose\u003c\/th\u003e\n\u003cth\u003eOn the syringe\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eStarting\u003c\/td\u003e\n\u003ctd\u003e1mg daily\u003c\/td\u003e\n\u003ctd\u003e10 units (0.1ml)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003ctd\u003e2mg daily\u003c\/td\u003e\n\u003ctd\u003e20 units (0.2ml)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eVial duration at standard dose: 10 days\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to inject:\u003c\/strong\u003e Evening preferred, at least 2 hours after your last meal. This aligns with the body's natural growth hormone release during sleep.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCycle length:\u003c\/strong\u003e 8 to 12 weeks, then reassess.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp class=\"pp-sub\"\u003eHow to inject\u003c\/p\u003e\n\u003col class=\"pp-step\"\u003e\n\u003cli\u003eWipe your injection site with an alcohol swab and let it dry\u003c\/li\u003e\n\u003cli\u003ePinch a small fold of skin on your abdomen\u003c\/li\u003e\n\u003cli\u003eInsert the needle at a 45-degree angle into the pinched skin\u003c\/li\u003e\n\u003cli\u003eSlowly push the plunger down until empty\u003c\/li\u003e\n\u003cli\u003ePull the needle out and apply gentle pressure with the swab\u003c\/li\u003e\n\u003cli\u003eDispose of the needle safely in a sharps container — never recap or reuse\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"pp-sub\"\u003eStorage\u003c\/p\u003e\n\u003cp\u003eKeep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"pp-fig\"\u003e\u003cimg class=\"pp-img\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-reconstitution-steps-v2.png?v=1786504935\" alt=\"Four-step peptide reconstitution guide: bring the vial to room temperature, add bacteriostatic water down the vial wall, roll gently without shaking, and store refrigerated at 2 to 6 degrees Celsius without freezing\" width=\"1400\" height=\"900\" loading=\"lazy\" decoding=\"async\"\u003e\u003c\/figure\u003e\n\u003cp style=\"margin-top:26px\"\u003e\u003ca class=\"pp-cta\" href=\"#specs\" onclick=\"window.scrollTo({top:0,behavior:'smooth'});return false;\"\u003eReady to order — back to the top\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-sec pp-alt\" id=\"faq\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eQuestions\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does tesamorelin differ from exogenous growth hormone?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eRecombinant growth hormone supplies the hormone directly, overriding pituitary regulation. Tesamorelin acts one step upstream at the GHRH receptor, amplifying the pituitary's own pulsatile secretion. Somatostatin tone and IGF-1 negative feedback remain intact, so the physiological pattern of release is preserved in research models.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow does it differ from ipamorelin or CJC-1295?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eIpamorelin is a ghrelin receptor (GHS-R1a) agonist — a different receptor and a different pathway. CJC-1295 is the closer comparator, being a GHRH analogue, though of different structural design. Tesamorelin is the GHRH analogue with the most substantial randomised controlled trial literature behind it.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhat has tesamorelin been studied for?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eIts principal published trials examined visceral adipose tissue in HIV-associated lipodystrophy (Falutz et al., NEJM, 2007, and a pooled phase 3 analysis) and hepatic fat in non-alcoholic fatty liver disease in HIV (Stanley et al., Lancet HIV, 2019). Purist supplies the compound for laboratory research only.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eWhy is visceral fat a distinct research target?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eVisceral adipose tissue differs from subcutaneous fat in receptor density, lipolytic responsiveness and metabolic activity. It is comparatively rich in growth hormone receptors, which is the mechanistic basis for the tissue-selective effects reported in the tesamorelin trials.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow is purity verified?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eEvery batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at \u003ca href=\"\/pages\/quality-standards\"\u003eQuality Standards\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eHow long does delivery take?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eOrders are dispatched from South Africa, with timelines varying by region and courier. Current dispatch and transit windows are set out at \u003ca href=\"\/pages\/delivery-process\"\u003eDelivery Process\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\u003cdetails class=\"pp-ac\"\u003e\u003csummary\u003eCan I return an order?\u003c\/summary\u003e\u003cdiv class=\"pp-ab\"\u003e\u003cp\u003eBecause these are laboratory compounds, returns are not accepted once an order has shipped. If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out in our \u003ca href=\"\/policies\/refund-policy\"\u003eRefund Policy\u003c\/a\u003e.\u003c\/p\u003e\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"pp-links\"\u003e\u003cdiv class=\"pp-in\"\u003e\n\u003cp class=\"pp-kick\"\u003eExplore\u003c\/p\u003e\n\u003cdiv class=\"pp-chips\"\u003e\n\u003ca class=\"pp-chip pp-chip-lead\" href=\"\/collections\/fat-loss-peptides\"\u003eAlso in Fat Loss \u0026amp; Metabolic Research\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/retatrutide\"\u003eRetatrutide\u003c\/a\u003e\u003ca class=\"pp-chip\" href=\"\/products\/cjc-1295-w-dac\"\u003eCJC-1295 w DAC\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/visceral-fat-peptide-stack\"\u003eVisceral Fat Peptide Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/gh-optimisation-peptide-stack\"\u003eGH Optimisation Peptide Stack\u003c\/a\u003e\u003ca class=\"pp-chip pp-chip-alt\" href=\"\/pages\/metabolic-reset-peptide-stack\"\u003eMetabolic Reset Peptide Stack\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"How does tesamorelin differ from exogenous growth hormone?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Recombinant growth hormone supplies the hormone directly, overriding pituitary regulation. Tesamorelin acts one step upstream at the GHRH receptor, amplifying the pituitary's own pulsatile secretion. Somatostatin tone and IGF-1 negative feedback remain intact, so the physiological pattern of release is preserved in research models.\"}},{\"@type\":\"Question\",\"name\":\"How does it differ from ipamorelin or CJC-1295?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Ipamorelin is a ghrelin receptor (GHS-R1a) agonist, a different receptor and a different pathway. CJC-1295 is the closer comparator, being a GHRH analogue, though of different structural design. Tesamorelin is the GHRH analogue with the most substantial randomised controlled trial literature behind it.\"}},{\"@type\":\"Question\",\"name\":\"What has tesamorelin been studied for?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Its principal published trials examined visceral adipose tissue in HIV-associated lipodystrophy (Falutz et al., NEJM, 2007, and a pooled phase 3 analysis) and hepatic fat in non-alcoholic fatty liver disease in HIV (Stanley et al., Lancet HIV, 2019). Purist supplies the compound for laboratory research only.\"}},{\"@type\":\"Question\",\"name\":\"Why is visceral fat a distinct research target?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Visceral adipose tissue differs from subcutaneous fat in receptor density, lipolytic responsiveness and metabolic activity. It is comparatively rich in growth hormone receptors, which is the mechanistic basis for the tissue-selective effects reported in the tesamorelin trials.\"}},{\"@type\":\"Question\",\"name\":\"How is purity verified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Every batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at https:\/\/puristpeptides.co.za\/pages\/quality-standards.\"}},{\"@type\":\"Question\",\"name\":\"How long does delivery take?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Orders are dispatched from South Africa, with timelines varying by region and courier. Current dispatch and transit windows are set out at https:\/\/puristpeptides.co.za\/pages\/delivery-process.\"}},{\"@type\":\"Question\",\"name\":\"Can I return an order?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Because these are laboratory compounds, returns are not accepted once an order has shipped. If your parcel arrives damaged, contact us within 48 hours with photographs of the packaging and product and we will arrange a replacement. The full terms are set out at https:\/\/puristpeptides.co.za\/policies\/refund-policy.\"}}]}\u003c\/script\u003e","brand":"Purist Peptides","offers":[{"title":"Default Title","offer_id":51217973510442,"sku":"PP-TESA-01","price":2800.0,"currency_code":"ZAR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-peptides-tesamorelin-ghrh-analog-research-peptide-vial.jpg?v=1784719141"},{"product_id":"fat-loss-peptide-stack","title":"Fat Loss Stack — Complete 8-Week Cycle","description":"\u003cp\u003eThe fat loss peptide stack pairs Retatrutide with MOTS-C as a complete 8-week research cycle. Retatrutide works the appetite-signalling and energy-balance side; MOTS-C works the mitochondrial and metabolic-output side through AMPK activation. Because they act through entirely distinct mechanisms, they address fat loss from two complementary angles rather than doubling up on one pathway.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhat's in this cycle\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e1 × Retatrutide 30mg — covers the full 8-week titration (39mg used)\u003c\/li\u003e\n\u003cli\u003e2 × MOTS-C 40mg — covers 8 weeks at 10mg\/week\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eRetail if bought as separate vials: R6,000. Bundle price R5,400 — you save R600 (10%).\u003c\/p\u003e\u003cp\u003e\u003ca href=\"\/pages\/fat-loss-peptide-stack\"\u003eFull protocol, dosing and reconstitution guide →\u003c\/a\u003e\u003c\/p\u003e\u003cp\u003e\u003cem\u003eResearch use only. Not for human or veterinary consumption.\u003c\/em\u003e\u003c\/p\u003e","brand":"Purist Peptides","offers":[{"title":"Default Title","offer_id":52157690904874,"sku":"PP-STK-01","price":5400.0,"currency_code":"ZAR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-peptides-fat-loss-peptide-stack-complete-8-week-cycle_3f9e1b7d-1689-4e6c-932d-08a990115761.jpg?v=1785611792"},{"product_id":"visceral-fat-peptide-stack","title":"Visceral Fat Stack — Complete 8-Week Cycle","description":"\u003cp\u003eThe visceral fat peptide stack pairs Retatrutide with Tesamorelin as a complete 8-week research cycle. Visceral fat — the deep abdominal fat stored around the organs — is a distinct research target from subcutaneous fat, and Tesamorelin is the only GHRH analogue specifically studied for it.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhat's in this cycle\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e1 × Retatrutide 30mg — covers the full 8-week titration\u003c\/li\u003e\n\u003cli\u003e2 × Tesamorelin 20mg — covers 8 weeks at 5mg\/week (5 on \/ 2 off)\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eRetail if bought as separate vials: R7,600. Bundle price R6,840 — you save R760 (10%).\u003c\/p\u003e\u003cp\u003e\u003ca href=\"\/pages\/visceral-fat-peptide-stack\"\u003eFull protocol, dosing and reconstitution guide →\u003c\/a\u003e\u003c\/p\u003e\u003cp\u003e\u003cem\u003eResearch use only. Not for human or veterinary consumption.\u003c\/em\u003e\u003c\/p\u003e","brand":"Purist Peptides","offers":[{"title":"Default Title","offer_id":52157693329706,"sku":"PP-STK-02","price":6840.0,"currency_code":"ZAR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-peptides-visceral-fat-peptide-stack-complete-8-week-cycle_a3c910da-284a-479a-bf7b-e8898849aa59.jpg?v=1785611794"},{"product_id":"lean-growth-peptide-stack","title":"Lean Growth Stack — Complete 8-Week Cycle","description":"\u003cp\u003eThe lean muscle peptide stack pairs CJC-1295 w DAC with MOTS-C as a complete 8-week research cycle, targeting lean growth from both the hormonal (GH axis) and cellular energy (mitochondrial) angles.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhat's in this cycle\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e2 × CJC-1295 w DAC 5mg — covers 10 weeks; 2mg spare\u003c\/li\u003e\n\u003cli\u003e2 × MOTS-C 40mg — covers exactly 8 weeks at 10mg\/week\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eRetail if bought as separate vials: R6,400. Bundle price R5,760 — you save R640 (10%).\u003c\/p\u003e\u003cp\u003e\u003ca href=\"\/pages\/lean-growth-peptide-stack\"\u003eFull protocol, dosing and reconstitution guide →\u003c\/a\u003e\u003c\/p\u003e\u003cp\u003e\u003cem\u003eResearch use only. Not for human or veterinary consumption.\u003c\/em\u003e\u003c\/p\u003e","brand":"Purist Peptides","offers":[{"title":"Default Title","offer_id":52157694542122,"sku":"PP-STK-04","price":5760.0,"currency_code":"ZAR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-peptides-lean-growth-peptide-stack-complete-8-week-cycle_5445ac68-41b3-41e8-b897-1e5f04c9d104.jpg?v=1785611799"},{"product_id":"metabolic-reset-peptide-stack","title":"Metabolic Reset Stack — Complete 8-Week Cycle","description":"\u003cp\u003eThe metabolic reset peptide stack combines Retatrutide, NAD+ and MOTS-C as a complete 8-week research cycle — the only three-compound stack in the range and the most comprehensive metabolic protocol available.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhat's in this cycle\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e1 × Retatrutide 30mg — covers the full 8-week titration\u003c\/li\u003e\n\u003cli\u003e4 × NAD+ 1000mg — covers 8 weeks at 500mg\/week\u003c\/li\u003e\n\u003cli\u003e2 × MOTS-C 40mg — covers 8 weeks at 10mg\/week\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eRetail if bought as separate vials: R12,800. Bundle price R11,520 — you save R1,280 (10%).\u003c\/p\u003e\u003cp\u003e\u003ca href=\"\/pages\/metabolic-reset-peptide-stack\"\u003eFull protocol, dosing and reconstitution guide →\u003c\/a\u003e\u003c\/p\u003e\u003cp\u003e\u003cem\u003eResearch use only. Not for human or veterinary consumption.\u003c\/em\u003e\u003c\/p\u003e","brand":"Purist Peptides","offers":[{"title":"Default Title","offer_id":52157699850538,"sku":"PP-STK-10","price":11520.0,"currency_code":"ZAR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/files\/purist-peptides-metabolic-reset-peptide-stack-complete-8-week-cycle_382773e8-a713-4b6c-9445-5b065c783a66.jpg?v=1785611817"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0984\/2422\/6090\/collections\/hf_20260313_191709_4f43738e-950f-4738-b32e-59e5f6decda6.png?v=1786782077","url":"https:\/\/puristpeptides.co.za\/collections\/weight-loss-offering.oembed","provider":"Purist Peptides","version":"1.0","type":"link"}