Overview
In plain English
KLOW is the GLOW blend with a fourth peptide, KPV, added. One vial contains GHK-Cu 50mg, TB-500 10mg, BPC-157 10mg and KPV 10mg.
Three of the four are studied for the mechanics of repair — collagen maturation, cell migration, blood supply. KPV is studied for the inflammatory signalling that repair takes place in, through attenuation of NF-κB and MAP kinase pathways in published models. Strictly for laboratory research use. Not for human or veterinary consumption.
- What it isFour peptides in one vial: GHK-Cu, TB-500, BPC-157, KPV (80mg total)
- Mainly studied forMatrix maturation, cell migration, vascular supply and inflammatory signalling in repair models
- Supplied asLyophilised powder, single 80mg vial at a published fixed ratio, independently assayed
How it works
What it actually does
GHK-Cu delivers copper to the enzyme that locks collagen and elastin into mature, load-bearing fibres — the difference between making collagen and making collagen that holds.
TB-500 handles cell movement into the area. BPC-157 handles blood supply to it.
KPV is the piece the other three do not cover. It is the C-terminal tripeptide of alpha-MSH, an endogenous hormone, and in published models it retains the anti-inflammatory character of the parent molecule without the pigmentary activity.
The science in detail
KLOW is the GLOW combination with a fourth constituent added. Three of its four peptides address the mechanics of tissue repair; the fourth addresses the inflammatory environment in which that repair takes place.
GHK-Cu, the largest fraction at 50mg, is the tripeptide glycyl-L-histidyl-L-lysine complexed with copper(II). It binds Cu2+ with affinity comparable to serum albumin, but reversibly — accepting copper from albumin and delivering it to cellular transporters and cuproenzymes including lysyl oxidase, which cross-links collagen and elastin into mature fibrils. Pickart and Margolina (Int J Mol Sci, 2018) reported broad transcriptional modulation consistent with controlled matrix turnover rather than simple accumulation.
TB-500 derives from thymosin beta-4, the principal G-actin sequestering peptide in mammalian cells. It binds actin monomer 1:1 through its LKKTETQ motif, maintaining a reservoir that permits rapid localised polymerisation at a migrating cell's leading edge. Malinda et al. (Journal of Investigative Dermatology, 1999) reported accelerated dermal repair in rodent models.
BPC-157 is a 15-residue fragment of a protein isolated from human gastric juice. Hsieh et al. (Journal of Molecular Medicine, 2017) associated its pro-angiogenic activity with VEGFR2 activation and downstream Akt–eNOS signalling.
KPV is the distinguishing constituent. It is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone — residues 11 to 13, Lys-Pro-Val — and retains the parent hormone's anti-inflammatory character without its melanocortin receptor-mediated pigmentary activity. Dalmasso et al. (Gastroenterology, 2008) reported that KPV is taken up by the intestinal di/tripeptide transporter PepT1 and reduces inflammation in murine colitis models at low concentrations, the described intracellular effect being attenuation of NF-κB and MAP kinase signalling. Because it enters cells by an active transporter rather than a surface receptor, its pharmacology is unlike the other three.
No controlled study of the four-compound combination has been published.
Evidence
What the research shows
Four peptides, four different jobs
Collagen maturation, cell migration, blood supply and inflammation are handled separately.
KPV is the differentiator vs GLOW
It carries the anti-inflammatory signalling component of alpha-MSH without the melanocortin-receptor pigmentary activity.
Fixed ratio
The blend is manufactured at set quantities; the constituents cannot be varied independently from one vial.
No study of the four together
Each constituent has its own literature; the combination itself is untested in controlled trials.
Reconstitution & handling
Reconstitution and handling in the laboratory
These are general handling notes for the lyophilised peptide supplied by Purist Peptides. They describe the preparation of a stock solution for laboratory work. They are not a dosing protocol, and they describe no administration to a person or an animal.
A 3ml vial of bacteriostatic water is included free with every peptide vial you order, so the material can be reconstituted on arrival.
KLOW — GHK-Cu 50mg + TB-500 10mg + BPC-157 10mg + KPV 10mg — preparing a stock solution
Choice of diluent
Bacteriostatic water (water for injection with 0.9% benzyl alcohol) is the usual diluent where a stock will be drawn from repeatedly, because the preservative permits several septum entries across a working period. Sterile water for injection and sterile 0.9% sodium chloride are both used where a single-use preparation is wanted instead. The diluent volume sets the concentration of the stock, so record it.
Sterile technique
- Allow the sealed vial to reach room temperature before opening the carton — reconstituting a cold lyophilised cake slows dissolution
- Work in a clean area or a laminar flow cabinet, and wipe the rubber septum with 70% isopropyl alcohol, letting it dry fully
- Draw the chosen volume of diluent using a sterile single-use syringe and needle
- Angle the needle so the diluent runs down the inside wall of the vial — do not direct the stream onto the lyophilised cake
- Roll the vial gently between the palms until the cake has dissolved completely. Do not shake and do not vortex: peptides are surface-active, and agitation drives foaming and aggregation
- Let the vial stand for 5 to 10 minutes. A correctly reconstituted solution is clear and free of visible particles
Working out the concentration
Concentration follows from the mass in the vial and the volume of diluent added, nothing else. Adding 3ml of diluent to the 80mg vial gives a stock of approximately 26.7mg/ml total peptide (16.7mg/ml GHK-Cu and 3.3mg/ml each of TB-500, BPC-157 and KPV); adding 2ml gives 40mg/ml total. Label every reconstituted vial with its concentration and the date it was prepared.
Storage and stability
Before reconstitution
The lyophilised powder is the stable form. Sealed vials are best held at −20°C, protected from light and from moisture; the short periods at 2 to 6°C that occur in transit and on arrival are expected and are accounted for in the supply chain. Keep the vial in its carton — light and humid air are the two ordinary causes of loss on storage.
After reconstitution
Hold reconstituted solution at 2 to 6°C and protect it from light. Do not freeze a working stock: freeze-thaw cycling is the main avoidable cause of degradation and of visible precipitate. Where material must be held beyond a short working period, aliquot the stock into sterile low-binding tubes and freeze the aliquots once at −20°C or below, thawing each aliquot only once.
Checks before use
Inspect every vial against a light source. Discard any solution that is hazy, discoloured or contains particles, and any vial whose septum integrity is in doubt. The independent HPLC assay report for the batch supplied is available on request.
A correctly reconstituted KLOW solution is blue to blue-violet from the coordinated copper(II) of GHK-Cu. Loss of colour or a marked colour shift suggests dissociation of the copper complex.
Strictly for laboratory research use. Not for human or veterinary consumption.
Questions
Frequently asked questions
What is the difference between KLOW and GLOW?
KPV, and the total peptide content. GLOW is GHK-Cu, TB-500 and BPC-157 at 70mg total. KLOW is the same three at a published split of 50mg, 10mg and 10mg, plus 10mg of KPV, for 80mg total. KPV addresses inflammatory signalling rather than the mechanics of repair.
What is KPV and why is it included?
KPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone, residues 11 to 13. It carries the parent hormone's anti-inflammatory activity without the melanocortin receptor engagement responsible for pigmentation. Dalmasso et al. (Gastroenterology, 2008) described its uptake through the PepT1 transporter and its effect on NF-κB signalling in murine colitis models.
Is there research on the four-compound blend itself?
No. No controlled study of these four peptides administered together has been published. The evidence base is separate preclinical work on each. The combination is a formulation convention grounded in mechanistic non-overlap and should be described as such, not as a validated protocol.
Is the ratio of the four peptides published?
Yes. The product page states GHK-Cu 50mg, TB-500 10mg, BPC-157 10mg and KPV 10mg. This is a fixed ratio determined at manufacture and cannot be adjusted from a single vial.
How is purity verified?
Every batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our quality standards page.
How long does delivery take?
Orders are dispatched from within South Africa with tracking. Timelines by region and courier are set out on our delivery process page.
What is the returns policy?
Unopened vials in original condition may be returned within the stated window; full terms are in our refund policy.
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