Overview
In plain English
KLOW is the GLOW blend with a fourth peptide, KPV, added. One vial contains GHK-Cu 50mg, TB-500 10mg, BPC-157 10mg and KPV 10mg.
Three of the four target the mechanics of repair — collagen, cell movement, blood supply. KPV targets the inflammation that repair happens in. It is used where skin quality and recovery are both the goal and irritation is part of the picture.
- What it isFour peptides in one vial: GHK-Cu, TB-500, BPC-157, KPV (80mg total)
- Mainly used forSkin quality, tissue repair, inflammatory irritation
- Typical protocol2.67mg once daily for 8–12 weeks
How it works
What it actually does
GHK-Cu delivers copper to the enzyme that locks collagen and elastin into mature, load-bearing fibres — the difference between making collagen and making collagen that holds.
TB-500 handles cell movement into the area. BPC-157 handles blood supply to it.
KPV is the piece the other three do not cover. It is a three-amino-acid fragment of a hormone your body makes, and it retains the anti-inflammatory character of the parent molecule without the pigment effects.
The science in detail
KLOW is the GLOW combination with a fourth constituent added. Three of its four peptides address the mechanics of tissue repair; the fourth addresses the inflammatory environment in which that repair takes place.
GHK-Cu, the largest fraction at 50mg, is the tripeptide glycyl-L-histidyl-L-lysine complexed with copper(II). It binds Cu2+ with affinity comparable to serum albumin, but reversibly — accepting copper from albumin and delivering it to cellular transporters and cuproenzymes including lysyl oxidase, which cross-links collagen and elastin into mature fibrils. Pickart and Margolina (Int J Mol Sci, 2018) reported broad transcriptional modulation consistent with controlled matrix turnover rather than simple accumulation.
TB-500 derives from thymosin beta-4, the principal G-actin sequestering peptide in mammalian cells. It binds actin monomer 1:1 through its LKKTETQ motif, maintaining a reservoir that permits rapid localised polymerisation at a migrating cell's leading edge. Malinda et al. (Journal of Investigative Dermatology, 1999) reported accelerated dermal repair in rodent models.
BPC-157 is a 15-residue fragment of a protein isolated from human gastric juice. Hsieh et al. (Journal of Molecular Medicine, 2017) associated its pro-angiogenic activity with VEGFR2 activation and downstream Akt–eNOS signalling.
KPV is the distinguishing constituent. It is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone — residues 11 to 13, Lys-Pro-Val — and retains the parent hormone's anti-inflammatory character without its melanocortin receptor-mediated pigmentary activity. Dalmasso et al. (Gastroenterology, 2008) reported that KPV is taken up by the intestinal di/tripeptide transporter PepT1 and reduces inflammation in murine colitis models at low concentrations, the described intracellular effect being attenuation of NF-κB and MAP kinase signalling. Because it enters cells by an active transporter rather than a surface receptor, its pharmacology is unlike the other three.
No controlled study of the four-compound combination has been published.
Evidence
What the research shows
Four peptides, four different jobs
Collagen maturation, cell migration, blood supply and inflammation are handled separately.
KPV is the differentiator vs GLOW
It carries the anti-inflammatory part of alpha-MSH without the tanning activity.
Fixed ratio
The blend is manufactured at set quantities; the constituents cannot be dosed independently from one vial.
No study of the four together
Each constituent has its own literature; the combination itself is untested in controlled trials.
Mixing & dosage
How to mix and dose it
These are the mixing and dosage instructions supplied by Purist Peptides and the manufacturer for this product.
A 3ml vial of bacteriostatic water is included free with every peptide vial you order, so you have what you need to mix this on arrival.
KLOW Stack — BPC-157 10mg + TB-500 10mg + GHK-Cu 50mg + KPV 10mg
Step 1 — mix your vial
- Draw up 3ml of bacteriostatic water into a syringe
- Wipe the rubber top of your vial with an alcohol swab and let it dry
- Insert the needle then slowly and carefully push the water down the inside wall of the vial — do not inject water straight onto the peptide powder
- Gently roll the vial between your palms until the powder dissolves completely
- Do not shake
- Allow to settle in the fridge for 5–10 minutes. The liquid should look clear
Step 2 — draw & inject your dose
Use a 1ml insulin syringe to draw and inject your dose. A 1ml syringe = 100 units.
With 3ml of water added, each 0.1ml (10 units) you draw = 2.67mg of the total blend.
| Stage | Dose | On the syringe |
|---|---|---|
| Starting | 1.33mg daily | 5 units (0.05ml) |
| Standard | 2.67mg daily | 10 units (0.1ml) |
Vial duration at standard dose: 30 days
When to inject: Once daily, morning or evening, at a consistent time. Inject subcutaneously into the abdomen or near the area of concern.
Cycle length: 8 to 12 weeks, then reassess.
How to inject
- Wipe your injection site with an alcohol swab and let it dry
- Pinch a small fold of skin on your abdomen or inject near the area of concern
- Insert the needle at a 45-degree angle into the pinched skin
- Slowly push the plunger down until empty
- Pull the needle out and apply gentle pressure with the swab
- Dispose of the needle safely in a sharps container — never recap or reuse
Storage
Keep refrigerated at 2 to 6 degrees Celsius at all times after mixing. Do not freeze. Protect from light and label the vial with the date you reconstituted it. Discard any solution that is hazy, discoloured or contains particles.
For informational purposes only. This is not medical advice. Speak to a qualified healthcare professional before starting any compound.
Questions
Frequently asked questions
What is the difference between KLOW and GLOW?
KPV, and the total peptide content. GLOW is GHK-Cu, TB-500 and BPC-157 at 70mg total. KLOW is the same three at a published split of 50mg, 10mg and 10mg, plus 10mg of KPV, for 80mg total. KPV addresses inflammatory signalling rather than the mechanics of repair.
What is KPV and why is it included?
KPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone, residues 11 to 13. It carries the parent hormone's anti-inflammatory activity without the melanocortin receptor engagement responsible for pigmentation. Dalmasso et al. (Gastroenterology, 2008) described its uptake through the PepT1 transporter and its effect on NF-κB signalling in murine colitis models.
Is there research on the four-compound blend itself?
No. No controlled study of these four peptides administered together has been published. The evidence base is separate preclinical work on each. The combination is a formulation convention grounded in mechanistic non-overlap and should be described as such, not as a validated protocol.
Is the ratio of the four peptides published?
Yes. The product page states GHK-Cu 50mg, TB-500 10mg, BPC-157 10mg and KPV 10mg. This is a fixed ratio determined at manufacture and cannot be adjusted from a single vial.
How is purity verified?
Every batch is assayed by Bioindustrial Services in Boksburg, an independent biotechnology laboratory, using HPLC. We do not self-certify. The signed certificate of analysis for each batch — lab number, method and assayed result — is published on our quality standards page.
How long does delivery take?
Orders are dispatched from within South Africa with tracking. Timelines by region and courier are set out on our delivery process page.
What is the returns policy?
Unopened vials in original condition may be returned within the stated window; full terms are in our refund policy.
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