Overview
In plain English
Selank is a synthetic seven-amino-acid peptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed in Russia. It is an analogue of tuftsin, a naturally occurring immunomodulatory peptide.
It is studied in preclinical and clinical research for modulation of GABAergic signalling, for anxiolytic-like effects in preclinical models, and for effects on enkephalin-degrading enzymes. Strictly for laboratory research use. Not for human or veterinary consumption.
- What it isA synthetic heptapeptide analogue of the peptide tuftsin
- Mainly studied forGABAergic signalling, enkephalin-degrading enzymes
- Supplied asLyophilised powder, 10mg vial, independently HPLC assayed
How it works
What it actually does
Selank begins with the four residues of tuftsin (Thr-Lys-Pro-Arg) and ends in a Pro-Gly-Pro extension at the C-terminus, the same stabilising motif used in Semax.
Research interest centres on GABAergic signalling, the brain’s main inhibitory neurotransmitter system, and on anxiolytic-like effects observed in preclinical models.
Selank has also been studied for its effects on enzymes that break down enkephalins, the body’s own opioid peptides.
The science in detail
Tuftsin is a naturally occurring tetrapeptide (Thr-Lys-Pro-Arg) released from the heavy chain of immunoglobulin G, and is known for immunomodulatory activity. Selank was developed in Russia by extending this sequence with a C-terminal Pro-Gly-Pro motif, giving the heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro.
The Pro-Gly-Pro extension is intended to improve stability: short peptides such as tuftsin are rapidly degraded by peptidases, and the added tail slows that breakdown in experimental systems.
Mechanistic studies have focused on GABAergic signalling. Work in rodents has reported changes in the expression of genes involved in GABAergic neurotransmission, and Selank has been examined for anxiolytic-like effects in preclinical behavioural models.
A separate line of research concerns enkephalin-degrading enzymes. Selank has been reported to inhibit enzymes that break down enkephalins, which would be expected to prolong the activity of these endogenous opioid peptides. As with Semax, much of the literature comes from Russian research groups.
Evidence
What the research shows
Built on tuftsin
Selank extends tuftsin, a four-residue immunomodulatory peptide, into a heptapeptide.
Stabilised by Pro-Gly-Pro
The same C-terminal extension used in Semax was added to slow enzymatic breakdown.
GABAergic signalling
Rodent studies report changes in GABA-related gene expression and anxiolytic-like effects.
Enkephalin-degrading enzymes
Selank has been reported to inhibit enzymes that break down enkephalins.
Questions
Frequently asked questions
What is Selank studied for?
Published work covers modulation of GABAergic signalling, anxiolytic-like effects in preclinical behavioural models, and inhibition of enkephalin-degrading enzymes. Much of the literature originates from Russian research groups. Purist supplies the compound for laboratory research only.
How does Selank relate to tuftsin?
Tuftsin is a naturally occurring immunomodulatory tetrapeptide, Thr-Lys-Pro-Arg. Selank keeps that sequence and adds a Pro-Gly-Pro extension, giving the heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro.
Why does Selank carry a Pro-Gly-Pro extension?
Short peptides are rapidly degraded by peptidases. The Pro-Gly-Pro C-terminal extension was added to improve stability against that breakdown in experimental systems. Semax carries the same extension.
How does Selank differ from Semax?
Both are synthetic heptapeptides developed in Russia that end in Pro-Gly-Pro. Selank is derived from tuftsin and is researched mainly for GABAergic signalling; Semax is derived from the ACTH(4–10) fragment and is researched mainly for neurotrophic signalling.
How is purity verified?
Every batch is assayed by independent HPLC at Bioindustrial Services in Boksburg. We do not rely on the manufacturer's own certificate alone. The assay report for the batch you receive is available on request, and our full testing protocol is set out at Quality Standards.
How long does delivery take?
Orders are dispatched from South Africa, with timelines varying by region and courier. Current dispatch and transit windows are set out at Delivery Process.
What is the returns policy?
Unopened vials in original condition may be returned under the conditions set out at Refund Policy.
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